Interactions between suxamethonium and non-depolarizing neuromuscular blocking drugs
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چکیده
منابع مشابه
Interactions between suxamethonium and non-depolarizing neuromuscular blocking drugs.
In anaesthetized cats, we have confirmed that previously injected suxamethonium potentiates non-depolarizing neuromuscular blocking drugs whereas, when injected during the block, suxamethonium antagonizes the paralysis. We have attempted to explain these interactions by studying the effects of suxamethonium on extracellularly recorded nerve ending waveforms that correspond to the ionic currents...
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When a clinical dose of a competitive neuromuscular blocking drug is given I.V. to a patient, a period of latency is followed by a progressive onset of blockade until a maximum is reached after several minutes. Thereafter, the intensity of block declines gradually. The precise relationship between the dose of drug and the time-course of the effect is complex, being dependent upon both pharmacok...
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We have studied the effect of prior administration of non-depolarizing neuromuscular blocking drugs on suxamethonium-induced increases in masseter muscle tension in 21 children aged 3-10 yr, anaesthetized with nitrous oxide and halothane using supramaximal stimulation of the ulnar nerve and the nerve to masseter. Resting tension and isometric force of contraction were measured in the adductor p...
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were taken from this mixture at nine intervals for up to 128 min. Each sample was immediately acidified, stored at — 20 °C and subsequently transferred to Groningen for analysis. All samples revealed vecuronium without any of its breakdown products. Unlike the 3-hydroxy metabolite, neither of the two other metabolites of vecuronium (17-hydroxy and 3,17-dihydroxy vecuronium) have been detected p...
متن کاملThe role of the non-depolarizing drugs in the prevention of suxamethonium bradycardia.
Evidence has been presented to show that a second dose of suxamethonium is capable of producing a severe bradycardia in man. This response may be effectively prevented by the prior administration of certain non-depolarizing muscle relaxants namely tubocurarine, alcuronium, c-toxiferine and pancuronium in quantities of one-quarter or less of their muscle relaxant level. It is suggested that suxa...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1994
ISSN: 0007-0912
DOI: 10.1093/bja/72.2.198